Aerosolized pentamidine as second line therapy in patients with AIDS and Pneumocystis carinii pneumonia.

Successful treatment with aerosolized pentamidine of Pneumocystis carinii pneumonia in rats.

We examined both the therapeutic efficacy and tissue distribution of aerosolized pentamidine in immunosuppressed rats with Pneumocystis carinii pneumonia. In rats immunosuppressed by 5 weeks of pretreatment with dexamethasone, a 2-week course of 5 mg of aerosolized pentamidine per kg per day, administered free or encapsulated in the drug carrier system (liposomes), eradicated P. carinii pneumon...

Treatment and prophylaxis of Pneumocystis carinii pneumonia.

Trimethoprim-sulfamethoxazole and parenteral pentamidine isethionate are effective in 60 to 80 per cent of AIDS patients with pneumocystis pneumonia. Adverse reactions are frequent with both agents, but because the adverse reactions are less severe with trimethoprim-sulfamethoxazole, this agent is the drug of choice for patients who are not known to be intolerant of it. The recommended duration...

RSPT 2317 Anti-Infectives & Antibiotics AEROSOLIZED ANTI-INFECTIVE AGENTS Generic name: Pentamidine isethionate Brand name: NebuPent Mode of action: Pentamidine is an antiprotozoal, active against Pneumocystis carinii, the causative organism of Pneumocystis carinii pneumonia (PCP) in patients

Bilateral pneumothoraces hasten mortality in AIDS patients receiving secondary prophylaxis with aerosolized pentamidine. Association with a lower Dco prior to receiving aerosolized pentamidine.

We have administered aerosolized pentamidine (AP) to 48 AIDS patients for secondary prophylaxis of Pneumocystis carinii pneumonia (PCP). Pentamidine 60 mg was administered by ultrasonic nebulization (Fisoneb) five times during the first two weeks and then every two weeks. The mean follow-up was 343 +/- 22 days. PCP recurred in ten patients, 297 +/- 33 days after starting AP therapy. All respond...

Catheter-related infections and associated septicemia.

Communications to the Editor not have active Pneumocystis carinii pneumonia (PCP). All of these patients had a history of single or recurrent episodes of PCP and were receiving aerosolized pentamidine isethionate as prophylaxis against recurrence of PCP It was suspected that the pneumothoraces were caused by coughing due to the irritative effect of pentamidine therapy on the airways superimpose...